Lupron Depot — terrified to take lupron for endometriosis?

Lupron Depot 3.75 mg — How long after you stop taking Lupron do the side-effects last?

I don’t have an answer more of another question on this. I had 2 Lupron shots in 6 months back in 2011. It cause me to gain A LOT of weight. It has been over 5 years and my hair is thin, I have cyst acne, and struggle hard with weight. I was 178 at time of shot now 230. I want to know if these problems are side effects left over from these shot treatments?
I have had my thyroid checked doctors say it is in untreatable range. I am tired and I think have worse night sweats that now leave a sour smell. I am a very clean person who cares a great deal on how they look. Doctors can not tell me why these things are happening. I just started wondering if it was from Lupron. Because that is when everything went down hill for me.

It did help my endorsement pain along with removal of the cells. I also got curly beach waves in my hair from the shot. But over the past 5 years it has become very thin.

Has anyone else had long term side effects or things you can not get an answer on?

Votes: 1

i believe that suzanne66 gave the best (scientific) answer 8 years ago, although it probably doesn’t mean much to the rest of us… i am taking the 3-month cycle of lupron shots for prostate cancer… i always imagined that the weight gain was tied to the decrease in testosterone necessary to starve the cancer and lower one’s PSA… that has certainly worked in my case and lowered my PSA from 248 to 0.49… i have also gained 20 pounds… my only side effects have hourly hot flashes and fatigue… the hot flashes affect my sleep, and while i’m not sleeping, hey, let’s see what’s in the fridge… my theory is that, if i could sleep more, i’d, by extension, eat less… i don’t know what else they prescribe lupron for, but in my case it’s certainly doing its job and i have no real complaints…


i’ve only been on the shots for 5 months and have not yet experienced any side effects that would make me wish that hadn’t started the treatment…

In clinical trials, the most common side effects of LUPRON DEPOT, occurring in {amp}gt;10% of patients, include hot flashes/sweats, headache/migraine, decreased libido, depression/emotional lability, dizziness, nausea/vomiting, pain, vaginitis, and weight gain.1

When LUPRON DEPOT is used alone, bone thinning and hot flashes can occur. Along with LUPRON DEPOT injections, your doctor may prescribe Add-back* therapy. Add-back* is a daily pill that you take while on LUPRON DEPOT therapy to add back a small amount of the hormone progestin, which can help you manage certain side effects, without interfering with the way LUPRON DEPOT works.1,5

Add-back* may be prescribed from Day 1 of initial treatment with LUPRON DEPOT. Add-back* is not for everyone and should not be taken by women who currently have or have had any clotting disorder, heart disease, stroke, impaired liver function or liver disease, or breast cancer.1
Click here to learn how to save on Add-back* therapy.

*Norethindrone acetate 5 mg daily.1

Clinical Trials

In the majority of patients testosterone levels increased above baseline during the first week, declining thereafter to baseline levels or below by the end of the second week of treatment.

This transient increase was occasionally associated with a temporary worsening of signs and symptoms, usually manifested by an increase in bone pain (see WARNINGS). In a few cases a temporary worsening of existing hematuria and urinary tract obstruction occurred during the first week.

Potential exacerbations of signs and symptoms during the first few weeks of treatment is a concern in patients with vertebral metastases and/or urinary obstruction which, if aggravated, may lead to neurological problems or increase the obstruction.

In a comparative trial of LUPRON INJECTION (leuprolide acetate) versus DES, in 5% or more of the patients receiving either drug, the following adverse reactions were reported to have a possible or probable relationship to drug as ascribed by the treating physician.

Number of Reports
Cardiovascular System
  Congestive heart failure 1 5
  ECG changes/ischemia 19 22
  High blood pressure 8 5
  Murmur 3 8
  Peripheral edema 12 30
  Phlebitis/thrombosis 2 10
Gastrointestinal System
  Anorexia 6 5
  Constipation 7 9
  Nausea/vomiting 5 17
Endocrine System
  *Decreased testicular size 7 11
  *Gynecomastia/breast tenderness or pain 7 63
  *Hot flashes 55 12
  *Impotence 4 12
Hemic and Lymphatic System
  Anemia 5 5
Musculoskeletal System
  Bone pain 5 2
  Myalgia 3 9
Central/Peripheral Nervous System
  Dizziness/lightheadedness 5 7
  General pain 13 13
  Headache 7 4
  Insomnia/sleep disorders 7 5
Respiratory System
  Dyspnea 2 8
  Sinus congestion 5 6
Integumentary System
  Dermatitis 5 8
Urogenital System
  Frequency/urgency 6 8
  Hematuria 6 4
  Urinary tract infection 3 7
  Asthenia 10 10
* Physiologic effect of decreased testosterone.

In this same study, the following adverse reactions were reported in less than 5% of the patients on LUPRON.

Cardiovascular SystemAngina, Cardiac arrhythmias, Myocardial infarction, Pulmonary emboli; Gastrointestinal System—Diarrhea, Dysphagia, Gastrointestinal bleeding, Gastrointestinal disturbance, Peptic ulcer, Rectal polyps;

Endocrine SystemLibido decrease, Thyroid enlargement; Musculoskeletal System—Joint pain; Central/Peripheral Nervous System—Anxiety, Blurred vision, Lethargy, Memory disorder, Mood swings, Nervousness, Numbness, Paresthesia, Peripheral neuropathy, Syncope/blackouts, Taste disorders;

Respiratory System—Cough, Pleural rub, Pneumonia, Pulmonary fibrosis; Integumentary SystemCarcinoma of skin/ear, Dry skin, Ecchymosis, Hair loss, Itching, Local skin reactions, Pigmentation, Skin lesions;

Urogenital SystemBladder spasms, Dysuria, Incontinence, Testicular pain, Urinary obstruction; Miscellaneous—Depression, Diabetes, Fatigue, Fever/chills, Hypoglycemia, Increased BUN, Increased calcium, Increased creatinine, Infection/inflammation, Ophthalmologic disorders, Swelling (temporal bone).

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