Losing weight fast on duloxetine/cymbalta?

Does Cymbalta (duloxetine) cause weight gain or weight loss?

I started taking cymbalta for depression in 2006 at the age of 45 and gained almost 100 pounds in less than 2 years. My waist increased by 8 inches. I developed type 2 diabetes and became increasingly more depressed. And although my eating habits didn’t change and I could not understand why I got so heavy, i had no idea it was because of the cymbalta. It wasn’t until I changed doctors and he made me aware, weaning me off cymbalta and onto prozac.

I’m happier now, but losing that weight is a long hard battle. Had I known then it would reek havoc in my life and on my body, I never would have started it. For 7 years I took 90mg (one 60 and one 30mg tablet, increased because I was still depressed). Now I walk with a cane, lost the cartilage in my knee and have difficulty getting around. I feel like an old man at 52.

Be careful with this drug. I wish you all the best.

I take 60mg cymbalta daily, I lost a small amount of weight, 4kg, at first it helps me not to binge. I suppose it’s the antidepressant.
It doesn’t help with my pain, though!

Also, I take SR tramadol and meloxicam, aspirin , lasix and endone when needed for fibro and migraines. I had all this and more before I started the cymbalta . (My GP knows about interactions ie. Potentially seratonin syndrome)
I do feel much better generally and am even taking an interest in my plants and craft again.
I never lost my love of cooking, lol, though it can be a challenge to omit gluten, corn, soy and nuts.

I know this is an older thread, but still wanted to post my experience on Cymbalta. First off, I truly do believe there is something to the increase in sweets—especially at night/middle of the night. Even as a kid I never really craved sweets. But this has changed all within the timeframe I’ve been on Cymbalta. I, too have had a significant weight gain especially the past few years. My dosage has been up to 90mg but currently I’m back at 60mg.

Prior to taking Cymbalta I had bad migraines. My migraines decreased dramatically on this. That’s a plus!! But I also suffer from SI joint pain {amp}amp; I haven’t noticed any improvement in regard to pain management there.


When I first started Cymbalta, I felt incredible! That had never happened to me previously when beginning/taking any antidepressants the past 20-ish years I’ve been being treated for depression/anxiety. But then one day it just stopped working for me. I hung in there for a while then worked with my doctor to change meds.

While weaning off Cymbalta, my doctor started me on Fetzima. OMG. I’ve had withdrawal before but this was unbelievable! At one point I figured my husband is going to have to commit me because I was an emotional mess. I was so sick with these constant brain zaps {amp}amp; couldn’t work or really function. Just lay in the bed and cry. We went back up on the Cymbalta again {amp}amp; haven’t changed since. I’ve searched the web {amp}amp; found a good deal of folks have suffered similarly when trying to wean off Cymbalta. It also doesn’t help that it’s only manufactured in 20, 30 or 60mg capsules. I found other info related to actually counting crystals to wean off a little easier. I did ask my doctor about this {amp}amp; he said we can try this after the holidays if I want.

Another observation I made is that I don’t find Cymbalta effective at all for treating my anxiety. Does anyone else feel this way? I take Klonopin at night but not exactly the best fit for me, either. Also during this «Cymbalta period» I’ve had trouble with my heart rate too high. I’m now always being turned down to donate blood. Finally was sent to a Cardiologist who told me that this is a result of the meds I take for depression, anxiety {amp}amp; ADHD (Adderall). Now I take yet another medication to control the tachycardia!!!

Sorry this is so lengthy!! I wanted to share my experiences as well hoping to help others, too. Hoping everyone is able to find something that works for them!

I do not take cymbalta, but I checked the list of possible side effects and a less serious one is loss of appetite.

General side effects including insomnia (8% to 13%), fatigue (2% to 15%), *decreased appetite (3% to 11%)*, asthenia (2% to 8%), *anorexia (3% to 5%)*, pyrexia (1% to 3%), gait disturbance, and excessive yawning have been reported. Initial insomnia has been reported frequently. Trismus has also been reported.

Other side effects including *decreased appetite (8%)*, hot flushes (2% to 3%), *increased weight (2%)*, *decreased weight (2%)*, and tinnitus have been reported.

**In placebo controlled trials, patients treated with duloxetine for up to 9 weeks had an average weight loss of approximately 0.5 kg compared to an average weight gain of 0.2 kg in placebo treated patients.


Q: Does Cymbalta cause weight gain?

A: Cymbalta’s package insert lists sleep disorders and poor quality sleep as adverse reactions. Because your doctor knows your medical situation best, he/she is your best source of patient-specific medical information.

A: Cymbalta (duloxetine) is a serotonin-norepinephrine reuptake inhibitor used in the treatment of major depressive disorder and generalized anxiety disorder. Most common side effects of Cymbalta include nausea, dry mouth, constipation, somnolence, hyperhidrosis, and decreased appetite.

In clinical trials, patients treated with Cymbalta for up to 10 weeks experienced a mean weight loss of approximately 0.5 kilograms, compared with a mean weight gain of approximately 0.2 kilograms in placebo-treated patients.

In diabetic peripheral neuralgia studies, patients treated with Cymbalta for up to 13-weeks experienced a mean weight loss of approximately 1.1 kg, compared with a mean weight gain of approximately 0.

2 kg in placebo-treated patients. In fibromyalgia studies, patients treated with Cymbalta for up to 26 weeks experienced a mean weight loss of approximately 0.4 kg compared with a mean weight gain of approximately 0.

3 kg in placebo-treated patients. In one long-term fibromyalgia 60-week uncontrolled study, duloxetine patients had a mean weight increase of 0.7 kg. These are not all the possible side effects of Cymbalta.

A: If you decide that you want to discontinue Cymbalta, it’s important that you consult your physician or healthcare provider. According to Cymbalta’s package insert, if the decision has been made to discontinue Cymbalta, medication should be tapered, as rapidly as is feasible, but with recognition that discontinuation can be associated with certain symptoms.

A gradual reduction in the dose rather than abrupt cessation is recommended whenever possible. The following symptoms have been observed upon Cymbalta discontinuation: dizziness, nausea, headache, fatigue, burning or prickling sensation, vomiting, irritability, nightmares, insomnia, diarrhea, anxiety, excessive sweating, and vertigo.

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